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- Ugochukwu S. B. Anyaehie
- Eghosa E. Iyare
- Chiemeziem A. Obike
- Chinyere Aloke
- Darlington F. Chukwu
- Chinedum O. Eleazu
- Chukwuma J. Chukwu
- Ofovwe O. Ekakitie
- Nwaeze G. Konyefom
- Chinedu G. Uzomba
- John A. O. Chukwu
- Udu A. Ibiam
- Orji U. Obasi
- Nwogo A. Obasi
- Chuks O. Edeogu
- Patrick M. Aja
- Patience N. Ogbu
- Joseph C. Mordi
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U. Emelike, Chinedum
- Chemical Composition and Evaluation of Methanol Leaf Extract of Combretum dolichopetalum on Body Weights and Haematological Indices of Phenylhydrazine Induced-anaemic Rats
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Authors
Chinedum U. Emelike
1,
Ugochukwu S. B. Anyaehie
2,
Eghosa E. Iyare
2,
Chiemeziem A. Obike
3,
Chinyere Aloke
4,
Darlington F. Chukwu
1,
Chinedum O. Eleazu
5,
Chukwuma J. Chukwu
5,
Ofovwe O. Ekakitie
1,
Nwaeze G. Konyefom
1,
Chinedu G. Uzomba
6,
John A. O. Chukwu
7
Affiliations
1 Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Abakaliki, Ebonyi State, NG
2 Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu, NG
3 Department of Biochemistry, Michael Okpara University of Agriculture Umudike, Umuahia, Abia State, NG
4 Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Abakaliki, Ebonyi State, NG
5 Department of Chemistry/Biochemistry, Faculty of Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Abakaliki, Ebonyi State, NG
6 Department of Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Abakaliki, Ebonyi State., NG
7 7Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ebonyi State University, Abakaliki, Ebonyi State., NG
1 Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Abakaliki, Ebonyi State, NG
2 Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu, NG
3 Department of Biochemistry, Michael Okpara University of Agriculture Umudike, Umuahia, Abia State, NG
4 Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Abakaliki, Ebonyi State, NG
5 Department of Chemistry/Biochemistry, Faculty of Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Abakaliki, Ebonyi State, NG
6 Department of Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Abakaliki, Ebonyi State., NG
7 7Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ebonyi State University, Abakaliki, Ebonyi State., NG
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 28, No 2 (2021), Pagination: 135-144Abstract
Anaemia is a serious health challenge in developing countries. This study evaluated the chemical composition of Combretum dolichopetalum (CD) leaves, the effect of its methanol extract on the body weights and haematological indices of phenylhydrazine induced-anaemic rats. Fresh matured leaves of CD were collected, identified and authenticated. Phytochemicals, proximate compositions, mineral elements, anti-nutritional factors and Gas Chromatography-Mass Spectrometry (GC-MS) analysis were determined. A total number of twenty (20) mature inbred apparently healthy male albino rats of the Wistar strain (100-150 g) were used for this study. Anaemia was induced by administering phenylhydrazine to rats in Groups 2, 3 and 4 comprising of five rats per group. Group 1 (non-anaemic control) (n = 5) and Group 2 (anaemic control) received distilled water respectively while Groups 3 and 4 were administered 200 and 400 mg/kg of CD leaf extract orally using oropharyngeal cannula once per day for 28 days. Blood samples were obtained for haematological analysis using standard methods. The result showed a significant increase in Red Blood Cell (RBC), Packed Cell Volume (PCV) and haemoglobin concentration in Groups 3 and 4 compared with the anaemic group. Chemical analysis showed the presence of some phytochemicals, proximate compositions, mineral elements and anti-nutritional factors. GC-MS analysis showed the presence of nine (9) compounds. This study indicates that CD is nutritionally rich and contains someKeywords
Anaemia, Combretum dolichopetalum, Haematological Parameters, Mineral Elements, Phytochemicals, Proximate Compositions
References
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- Cleistopholis Patens Extracts Attenuate Inflammatory Cytokine and Oxidative Stress Status in Complete Freund’s Adjuvant-induced Rheumatoid Arthritis in Wistar Albino Rats
Abstract Views :106 |
PDF Views:0
Authors
Chinyere Aloke
1,
Udu A. Ibiam
2,
Orji U. Obasi
2,
Nwogo A. Obasi
1,
Chuks O. Edeogu
3,
Patrick M. Aja
2,
Chinedum U. Emelike
4,
Patience N. Ogbu
5,
Joseph C. Mordi
6
Affiliations
1 Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University Ndufu-Alike, Ebonyi State,, NG
2 Department of Biochemistry, Faculty of Sciences, Ebonyi State University, Abakaliki Ebonyi State,, NG
3 Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Ebonyi State University, Abakaliki Ebonyi State,, NG
4 Department of Physiology, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University Ndufu-Alike, Ebonyi State, NG
5 Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University Ndufu-Alike, Ebonyi State,
6 Department of Biochemistry, Delta State University, Abraka,, NG
1 Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University Ndufu-Alike, Ebonyi State,, NG
2 Department of Biochemistry, Faculty of Sciences, Ebonyi State University, Abakaliki Ebonyi State,, NG
3 Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Ebonyi State University, Abakaliki Ebonyi State,, NG
4 Department of Physiology, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University Ndufu-Alike, Ebonyi State, NG
5 Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University Ndufu-Alike, Ebonyi State,
6 Department of Biochemistry, Delta State University, Abraka,, NG
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 29, No 1 (2022), Pagination: 95-103Abstract
Rheumatoid Arthritis (RA) is an autoimmune inflammatory disease. Accumulating evidences show that natural products use for RA treatment is gaining importance in the medical world due to negative effects associated with orthodox medicines. This study investigated the anti-inflammatory and antioxidant potency of Stem Bark of Cleistopholis Patens (SBCP) on Chicken Type II collagen in Complete Freund’s Adjuvant (CFA) induced RA in rats. Experimental rats were divided into nine groups (n= 15). RA was established in the rats by a single intradermal injection of 0.1ml Chicken Type II collagen in CFA through the left hind paw. The serum concentrations of Inter-interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD) and catalase (CAT) were evaluated. Unlike the untreated arthritic group, the test groups (4-9) orally administered with graded doses (400, 600 and 800 mg/kg) of SBCP extracts for twenty-one days showed significant reduction (P < 0.05) in concentrations of IL-1β, IL-6, TNF-α, MDA and NO while the activities of SOD and CAT increased significantly (P < 0.05) when compared to the negative control. The anti-inflammatory and anti-oxidative effects of SBCP extracts were comparable to that of the reference drug, indomethacin. This study indicates that SBCP ethanol and aqueous extracts could suppress proinflammatory cytokines and reduce oxidative stress in rheumatoid arthritic rats.Keywords
Anti-Inflammatory, Antioxidants, Cleistopholis patens, Oxidative Stress, Rheumatoid Arthritis.References
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